Japan

This paper highlights the underexplored potential of chiral self-sorting in the design of switchable and metastable discrete supramolecular structures.

Researchers at Kanazawa University report in Nature Communications how they can control chirality inversion in α helical peptides.

Rapid preparation and application of a panel of clinical antibodies armed with B-BiTE for refractory malignancies

Researchers from Osaka University found that Japanese people who used medical information were more likely to wear masks and disinfect their hands even before the COVID-19 outbreak, while those who exchanged information with acquaintances were more likely to newly start mask-wearing and hand disinfection post outbreak. This will assist in the development of risk communication strategies to promote infection-preventive behavior in a timely manner.

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

Steel and aluminum are key players in supporting economic growth, yet materials joining them remain unexplored due to their fusion zones’ brittleness. A new 3D printing method’s fix may be a step toward a steel-aluminum hybrid renaissance.

New insights on how individual immune responses to the SARS-CoV-2 virus, particularly in mutant strains, can influence the efficacy of COVID-19 vaccines

A new study suggests that self-deception is the key to understanding irrational actions of national leaders in war, as exemplified by Vladimir Putin's invasion of Ukraine.

Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway. The findings may lead to a new approach for colorectal cancer therapy.

A research team led by Osaka University used 125 physical markers to understand the detailed mechanics of 44 different human facial motions. The aim was to better understand how to convey emotions with artificial faces. Beyond helping with the design of robots and androids, this research can also benefit computer graphics, facial recognition, and medical diagnoses.

Microscopes usually use backscattered radiation to create images, but a research group from the Institute of Industrial Science, The University of Tokyo, is developing an all-new method to study materials using the faint light they emit, generated by heat

Researchers at the Institute of Industrial Science, The University of Tokyo study the quantum mechanical phenomenon known as vacuum fluctuations using a nanoscale hybrid device, which may lead to ultrasensitive quantum sensors or information processors.

Future missions will be able to find signatures of violating the parity-symmetry in the cosmic microwave background polarization more accurately after a pair of researchers has managed to take into account the gravitational lensing effect, reports a new study in Physical Review D, selected as an Editors' Suggestion.

A researcher from Osaka University has investigated the associations between mask usage and the reasons people give for wearing a mask. Online surveys were conducted before and after policies that downgraded the status of COVID-19. The study found that 59% of respondents continued wearing masks even after policy changes. Several sociological and psychological reasons other than disease prevention for mask usage were identified.

Osaka University and NEC Corporation are jointly developing a data infrastructure called RED-ONION to accelerate open science by reducing the burden on researchers to record the research process, share research data and publish them on the data aggregation platform. They are currently engaged in the R & D of three elemental technologies: (1) Technology to integrate a data aggregation platform and data publication platform, (2) Technology to generate research process information on supercomputers, and (3) A high-speed data transmission function. These research results will be showcased at the International Conference for High Performance Computing, Networking, Storage, and Analysis (SC23) scheduled to be held from November 12 to 17, 2023 in Denver, Colorado.

Researchers at Kanazawa University report in the Journal of Physical Chemistry Letters high-speed atomic force microscopy studies that shed light on the possible role of the open reading frame 6 (ORF6) protein COVID19 symptoms.

To quickly and accurately characterize prospective materials for use in solar energy, researchers built an automated system to perform laboratory experiments and used machine learning to help analyze the data they recorded. Their goal is to identify semiconductor materials for use in photovoltaic solar energy, which are highly efficient and have low toxicity.

Research out of Osaka University finds an overlap in the mechanism of hair color determination and bone resorption, which is associated with bone related diseases like osteoporosis. The findings revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclast, cell specialized in the process. These proteins are also crucial for pigmentation of hair and skins.

Research from Osaka University demonstrates a nanopore-based technique that can detect different variants of SARS-CoV-2, the virus that causes COVID-19. The method was very effective in detecting the Omicron variant of the virus in the saliva of people with COVID-19.

Pair-bonded Java sparrows show enlarged eye rings to signal breeding readiness.

Research out of Osaka University investigated the effect of increased cell temperature on the contractility of skeletal muscle and cardiac muscle by heating the muscle proteins using advanced microscopical techniques. The findings indicated that skeletal muscle is more sensitive to increases in temperature than cardiac muscle, and that heating can rapidly activate the contractile proteins of skeletal muscle, thereby improving muscle performance.

Layered lithium cobalt oxide, a key component of lithium-ion batteries, has been synthesized at temperatures as low as 300°C and durations as short as 30 minutes.

Evaluation of developmental toxicity in early chicken embryos exposed to tris(2-chloroisopropyl) phosphate

This study examined how the origin (wild or hatchery-reared), feeding area (Baltic Sea mainstem, Bosnian Sea, and Gulf of Finland), and organic halogen compound (OHC) concentrations of Baltic Sea Atlantic salmon (Salmo salar) affect the salmon liver proteome, transcriptome, and oxidative stress markers. Results suggest that the Baltic salmon liver proteome, together with the transcriptome, is influenced more by OHC concentrations and oxidative stress levels in the feeding area than by their origin.

Structural characteristics of environmental pollutants and computer simulations predict effects on the endocrine system of seals

A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.

A research team from Osaka Metropolitan University has found that polysulfides are abundant in broccoli sprouts. They found that the amount of polysulfides increased dramatically during growth, by an approximately 20-fold in seeds by the fifth day of germination. Furthermore, a comprehensive analysis of the polysulfides detected a number of polysulfide candidates whose structures have not yet been determined. The identification of these unknown polysulfides and detailed analysis of their pharmacological activities are expected to enable the development of new preventive and therapeutic strategies and medicines for cancer, neurodegenerative diseases, stroke, inflammation, and other diseases.

Risk-averse on/off-target assessment for CRISPR editing without reference genome

The latest ‘large language model’ artificial intelligence system, GPT-4, could aid chemistry researchers, but limitations reveal the need for improvements.

Researchers from Osaka University developed a cell-friendly means of bioprinting at high fidelity. By successive injection of a cell-based ink and a printing support, the ink solidified into defined geometries, even into the shape of a human nose. Printed cells remained viable for at least two weeks. This work is an important milestone toward developing lab-grown tissues and organs, and eventually advancing regenerative medicine as well as animal-free drug safety testing.