Biology Structural Biology
News
14 May 2024
Genome editing is making inroads into biomedical research and medicine. By employing biomolecule modeling tools, a Japanese research team is accelerating the pace and cutting the cost of zinc finger nuclease (ZFN) technology, a primary gene editing tool.
22 Feb 2024
Researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications that TMEM16F, a transmembrane protein that facilitates the passive movement of phospholipids and ions across membranes, explores a larger conformational landscape than previously thought to perform its unique functions. The finding refines our molecular understanding of crucial physiological processes such as blood coagulation and COVID-19 pathogenesis, and highlights the importance of probing membrane proteins in native-like environments.
20 Dec 2023
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes. The findings provide insights into the mechanism behind the generation of cell-membrane action potentials.
08 Dec 2023
Researchers at Kanazawa University report in Frontiers in Molecular Biosciences a computational method to predict the placement of proteins on AFM substrates based on electrostatic interactions.
18 Aug 2023
Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes. Structural analysis and computer simulations made it possible to identify where and why calcium ions get stuck.
13 Mar 2023
Researchers at Kanazawa University report in ACS Nano how high-speed atomic force microscopy can be used to study the biomolecular mechanisms underlying gene editing.
28 Feb 2023
Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression. The process, revealed by means of high-speed atomic force microscopy, involves DNA and its packaging molecules.
20 Dec 2022
Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.
20 Jun 2022
Researchers at Kanazawa University report in Biophysics and Physicobiology how to optimize high-speed atomic force microscopy experiments on live cell membranes, so that moving objects like molecules can be properly followed from frame to frame.
15 Dec 2021
In a recent study published in the Journal of Extracellular Vesicles researchers from Kanazawa University have visualized structural changes on the surface of SARS-CoV-2 that enable it to enter human cells.
24 May 2021
In collaboration with Kanazawa University, researchers from Osaka City University used high-speed atomic force microscopy (HS-AFM) to visualize at the nanometer level the movement of individual particles within the parasitic bacterium Mycoplasma mobile. After confirming the outline on the surface of the cell structure in an immobilized state with previous data gathered from electron microscopy, the team succeeded in visualizing the real-time movements of the internal structure by scanning the outside of the cell with HS-AFM.
04 Mar 2021
Collecting liver tissue from 22 postoperative patients with long-term post-Fontan surgery, researchers have found a specific liver fibrosis to develop from the sinusoidal region which is difficult to accurately assess by conventional examination methods (ultrasound elastography and blood tests).
28 Dec 2020
Kanazawa University’s pioneering high-speed atomic force microscope technology has now shed light on the structure and dynamics of some of life’s most ubiquitous and inscrutable molecules – intrinsically disordered proteins. The study is reported in Nature Nanotechnology.
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Researchers
Dr. So Iwata is a Professor at the Graduate School of Medicine Kyoto University and the Group Director of the SACLA Science Research Group, RIKEN SPring-8 Center. He has investigated how specialized membrane channels remove antimicrobial drugs from inside bacterial cells.
Dr NK Prasanna is currently working as Sr. Scientist & Editor, Indian Journal of Biochemistry & Biophysics, Research Journals Division at CSIR-National Institute of Science Communication and Policy Research, New Delhi. Before joining CSIR (NIScPR), she was at IIT Guwahati. Dr Prasanna completed her Ph.D from Institute of Medical Sciences, Banaras Hindu University, Varanasi.
In CSIR-NIScPR, She served one important flagship journals viz. Indian journal of Biochemistry and Biophysics (IJBB; ISSN: 0301-1208) It is pertinent to mention that the journal ranks first among all the NIScPR journals as per the available Journal Metrics by international agencies such as Thomson Reuters and Scopus. Details of remarkable academic achievements of IJBB which she spearheading, both nationally and globally. The Indian journal of Biochemistry and Biophysics (IJBB) is a premier SCI-indexed bimonthly peer-reviewed research journal that publishes original research articles in the subject area of biochemistry and biophysics
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