Biotech

Contributing to embryogenesis and pathogenesis through long-term in vivo molecular imaging 1. Development of a two-photon excitation light-sheet microscope which achieves low phototoxicity, an extended field of view, and high resolution for the observation of the growth of living organisms 2. Applications of the microscope demonstrate long-term time-lapse observations for a three-day span of the embryonic development of medaka fish

Researchers have observed DNA spooling and unspooling in real time using CRISPR to attach fluorescent tags to very specific DNA points in living cells.

A spray-on magnetic coat turns any object into a robot controlled by a magnetic field. The biocompatible robots can walk, crawl and roll, and switch motions on demand.

Acetone, a volatile solvent used for everything from removing nail polish and cleaning textiles to manufacturing plastics, could get a sustainability boost from a new strain of bacteria engineered by a research team based in Japan.

A group of researchers have discovered that the cells that line the surfaces of organs or specific tissues – epithelial cells – asymmetrically release two types of exomes with distinct protein compositions. Their discovery could help understand how cancer spreads.

A new mouthwash developed in Malaysia, called Microencapsulated OroSYNTM, is expected to protect against oral diseases. The mouthwash made from banana skin and a bacterium promotes a healthy microbiome in the oral cavity to protect against diseases

A research team led by City University of Hong Kong (CityU) scientists recently developed a new generation of microneedles technology which allows the intradermal delivery of living cells in a minimally invasive manner. Their experiment showed that vaccination using therapeutic cells through this ground-breaking technology elicited robust immune responses against tumours in mice, paving the way for developing an easy-to-use cell therapy and other therapeutics against cancers and other diseases.

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the major treatment option, but the clinical result is unsatisfactory. A research team led by biologists at City University of Hong Kong (CityU) has identified and characterised a set of specific super-enhancers that stimulate the activity of the related critical cancer genes. The research has also discovered that the deletion of certain specific super-enhancers could reduce tumour cell growth. The latest findings may help discover new effective drug targets for TNBC patients to improve their survival chance.

Researchers from The University of Tokyo develop a novel device for the safe and effective transplantation of human induced pluripotent stem cell (iPSC)-derived pancreatic beta-cells in type I diabetes mellitus

New national body established to further research insights, improve patient outcomes and create new economic opportunities for the biomedical technology industry.

An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.

The University of Tokyo researchers use information theory to show that the accepted biochemical model of bacterial chemical sensing is mathematically equivalent to the optimal solution, with implications for microbiology and robotics

New research from Duke-NUS Medical School, and the Agency for Science, Technology and Research identifies chemotherapy-resistant cancers’ escape mechanism, which offers new anti-cancer treatment options.

Researchers at The University of Tokyo use the mathematics of adaptive learning and artificial intelligence to describe how T helper cells adjust the response of the vertebrate immune system, which may lead to new vaccines and treatments for infections

Researchers at The University of Tokyo develop a method of culturing meat in the laboratory in the form of millimeter-scale contractile beef muscle that closely simulates steak meat

Tohoku University Researchers tweaked the diet of silkworms by adding cellulose nanofiber to their food. The resultant silk was stronger and more durable. This new method of realizing cellulose nanofiber synthesized silk is a sustainable way to produce biomaterials.

An international team led by Professor Yilin Wu, Associate Professor of the Department of Physics at The Chinese University of Hong Kong (CUHK) has made a novel conceptual advance in the field of active matter science. The team discovered a new route in which the self-organisation of active fluids in space and time can be controlled by a single material property called viscoelasticity. This new finding may pave the way for fabricating a new class of self-driven devices and materials, such as the ability to control the rhythmic movement of soft robots without relying on electronic circuits, and for the study of microbial physiology. It has been published in the scientific journal Nature.

Undergraduate students explore a more efficient way to measure protein-containing vessels released by cells

Polyacrylamide gel electrophoresis enables high-resolution separation of proteins extracted from biological samples, but it requires more than one day of pretreatment to recover the separated proteins trapped inside the gel for detection by mass spectrometry. BAC-DROP, our novel electrophoresis technology, uses a dissolvable form of polyacrylamide gel, which allows sample pretreatment to be completed in about 5 hours. The developed technology will enable the rapid diagnosis of viruses and disease protein markers.

Researchers from DGIST have now found a way to keep living, wet cells viable in an ultra-high-vacuum environment, using graphene, allowing—like never before—accurate high-resolution visualization of the undistorted molecular structure and distribution of lipids in cell membranes. This could enhance our bioimaging abilities considerably, improving our understanding of mechanisms underlying complex diseases such as cancers and Alzheimer’s

A team of scientists in Japan has developed a novel method to induce stem cell generation from the blood samples of dogs. Through this technique, the scientists hope to advance regenerative therapies in veterinary medicine. This would mean that, in the near future, veterinarians might be able to reverse conditions in dogs that were previously thought incurable.

New ‘armoured’ T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection.

A research group compared how crickets adapt to limb removal, revealing more about adoptive locomotion and the mechanisms underpinning it.

Investigations of a cellular protein have uncovered a possible link with schizophrenia.

iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells.

A transporter protein that regulates cell membrane cholesterol likely played an important role in vertebrate evolution, according to a review published by iCeMS researchers in the journal FEBS Letters.

Daegu Gyeongbuk Institute of Science and Technology (DGIST) researchers gain deeper insight into a cell membrane channel, with potential implications for drug development.

An easy way to make millirobots by coating objects with a glue-like magnetic spray was developed in a joint research led by a scientist from City University of Hong Kong (CityU). Driven by the magnetic field, the coated objects can crawl, walk, or roll on different surfaces. As the magnetic coating is biocompatible and can be disintegrated into powders when needed, this technology demonstrates the potential for biomedical applications, including catheter navigation and drug delivery.

A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool

Far too little is known about the long-term dynamics of the abundance of most macro-organism species. We used sedimentary DNA technology to quantify marine fish DNA abundance in sediment sequences spanning the last 300 years. This study first shows the existence of fish DNA in the sequences and proves that fish abundance can be tracked using sedimentary DNA, highlighting the utility of sedimentary DNA for researchers to acquire lengthy records of macro-organism species abundance.