Medicine & Healthcare

Researchers from Osaka University developed an in vivo CRISPR screen to analyze factors affecting Toxoplasma gondii fitness in healthy and immunodeficient mice. Mice were infected with Toxoplasma containing CRISPR libraries that targeted specific genes; genetic sequencing was then performed to identify which genes are important to fitness. The genetic screen clarified the contributions of host genetics and parasite genetics and can contribute to the development of strategies for toxoplasmosis treatment and prevention.

App leads to better birth preparation for pregnant women

SUTD researchers developed a fully knitted, circuit-embedded knee wearable for wireless sensing of joint motion in real-time. Compared to other knitted electronics, this model has fewer externally integrated components and a more sensitive sensor, making it less error-prone.

Tests could soon identify patients who will respond well to the available treatment for chronic myeloid leukaemia and those who will be resistant to it—which could improve their chances of survival.

Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade - a novel form of cancer treatment utilizing immune checkpoint inhibitors - and minimizes the associated side effects. Using immune checkpoint blockades to target tumor-positive lymph nodes, they generated a robust anti-tumor response against both local and systemic metastases.

Eating fermented foods might be the secret to a healthy and long-lived society

Truck drivers unintentionally taking ‘microsleeps’ of a few seconds can cause terrible traffic accidents, but efforts and technologies aiming to prevent the problem have focused mainly on monitoring driver eye activity while missing a host of other key indicators of the problem.

Mushrooms 🍄get chattier after rainfall 🌧️, Two-organ chip answers fatty liver questions, History maps 🗺️vs future simulations, Restoring vision in blindness. Plus in our blog: Myanmar: Through eyes of leadership. Read all in the latest Editor's Choice.

Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy leads to insights into processes relevant to Alzheimer’s disease. Moreover, the technique is shown to be an excellent tool for studying the effect of drugs against the disease.

Researchers at Kanazawa University report in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) high-speed atomic force microscopy experiments that show how ligands associated with stimulating and suppressing activation of the TRPV1 protein increase and decrease the molecule’s structural variations. The observations provide insights into how these heat- and chilli-sensing proteins function.

Specially coated surfaces help scientists investigate what happens when cell clusters are turned upside down.

Researchers from Osaka University identified a new protein, R-spondin 3 (RSPO3), that has beneficial effects after ischemic stroke in mice. Specifically, RSPO3 activates the protein LGR4 to trigger a cascade of cellular reactions that decreases inflammation and stimulates the growth of neuronal extensions. Moreover, administrating RSPO3 to mice one day after stroke improved recovery of sensory and motor functions. These findings provide a new target for developing treatments to improve recovery after ischemic stroke.

A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

Osaka Metropolitan University scientists investigated the prevalence of antimicrobial resistant bacteria in 678 bacterial isolates from 428 companion dogs and 74 companion cats at the Veterinary Medical Center, Osaka Metropolitan University. Two E. coli strains have both a mobile colistin-resistant mcr gene and a third-generation cephalosporin-resistant blaCTX gene. One of these strains, which is found in a dog, was resistant to both colistin and third-generation cephalosporins.

HKBU joint research suggests that urine cytomegalovirus test facilitates early prediction of AIDS end-organ diseases

Polycyclic aromatic hydrocarbons, in particular, lower the prognosis of ischemic strokes by causing inflammation in the brain.

Singapore scientists find use of healthcare resources, absenteeism and reduced productivity due to mental health issues place a significant burden on Singapore’s economy.

A research group at the Osaka Metropolitan University analyzed the relationship between diet, muscle mass, and liver fibrosis progression in 136 patients with nonalcoholic fatty liver disease attending the Osaka Metropolitan University Hospital. The research group found that the group with the highest Japanese diet score had less advanced liver fibrosis, and that the intake of soy products, seafood, and seaweed was important.

The Nobel prize winning physicist Niels Bohr once said, “An expert is a (person) that has made all the mistakes that can be made in a narrow field.” This idea that to master a skill we must learn from our mistakes and avoid making them in future has long been recognized; however, the brain mechanisms and pathways that control this ability have been poorly understood. We revealed a specific brain pathway that allows us to identify and learn from our mistakes to guide better decision-making in future. Our work is an important step towards understanding how the brain controls our daily choices and behavior. The identification of these cells as ‘mistake signalers’ may also help to guide new treatments for mental health conditions associated with impaired decision-making ability.

Asia Research Newsは同所の女性研究者5名に、彼女らの研究について、そしてなぜKavli IPMUを選んだのか、これまでの同所での経験について話しを聞いた。それぞれ様々な背景を持ち、各分野で卓越している研究者らに、足かせのない女性がいかに飛躍できるかをみせてもらった。

Research reveals a promising stem cell approach to correct photoreceptor cell degeneration, which underlies several forms of visual decline and blindness.

Doctors at King Chulalongkorn Memorial Hospital have developed lightweight and easy-to-use Parkinson's gloves that can automatically reduce tremors, allowing patients to enjoy social life and reducing side effects from medication and risk from brain surgery.

The COVID-19 pandemic has made us more aware of the aerosols that hang around in the air and spread certain infectious diseases. Common dental procedures can be potentially hazardous in this regard. Therefore, it is crucial for researchers to be able to measure how aerosols spread so they can reduce them. A recent study harnessed a high-sensitivity camera and a high intensity LED light source, along with a mannequin and dental air turbine, to measure the spread of aerosols and the effectiveness of various means to reduce them.

A tiny platform empowers scientists to examine how gut and liver cells interact in health and disease.

Researchers from Osaka University found that the COMMD3/8 complex is implicated in the progression of the autoimmune response in a mouse model of rheumatoid arthritis. They identified celastrol, the active compound of a medicinal herb, as an inhibitor of the COMMD3/8 complex. Celastrol blocked the progression of rheumatoid arthritis. Thus, celastrol is a potential lead for developing treatments against rheumatoid arthritis.

- Research teams led by Professor Hongsoo Choi and Professor Yongseok Oh from DGIST joined the research team led by Dr. Jongcheol Rah from Korea Brain Research Institute to develop the technology for delivering a microrobot to a target point of a hippocampus in an in-vitro environment, connecting neural networks, and measuring neural signals - The research findings are expected to contribute to neural network research and the verification and analysis of cell therapy products

Researchers from Osaka Metropolitan University Graduate School of Medicine conducted an interoperative comparison of lateral disc meniscus injuries of young patients (aged 15 or less), that were treated with plastic sutures or subtotal resection, to see if there was a difference in postoperative cartilage degeneration. The research group observed that sub-total meniscectomies were more likely to show cartilage degeneration, being worst in lateral disc meniscus injuries. In addition, they found that even with higher levels of meniscus damage, preserving the meniscus with sutures was more effective in protecting the cartilage in young patients.

· Duke-NUS sleep scientists’ analyses show associations between early classes, less sleep, poor attendance and reduced grade point average. · Studies in secondary and junior college students have shown that later start times can have positive impacts on grades.

Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. It has also been reported that vesicles called exosomes produced by these CAFs play an important role in cancer progression. An Osaka Metropolitan University research group investigated the effect of CAF-derived exosomes on the growth of malignant melanoma cells. They found that CAF-derived exosomes express CD9 and CD63 transmembrane proteins, and that the CD9-positive exosomes may inhibit the growth of malignant melanoma cells.

Researchers from Osaka University have found that repeated high-dose treatment, known as pulse therapy, with the steroid methylprednisolone reduces in-hospital deaths in COVID-19 patients who receive invasive mechanical ventilation, but not in patients who don’t receive invasive mechanical ventilation. These findings were only possible using appropriate statistical methods to remove bias from the data, which originally seemed to show that the opposite was true. These results can improve patient treatment and reduce COVID-19-related deaths worldwide.